Erasmus Universitair Medisch Centrum Rotterdam  

EMC  Netherlands
  's-Gravendijkwal 2315 CE
(010) 704 0704
Principal Investigator(s):
  Dr. Wiro J. Niessen

List of researchers and collaborators involved in the project:

  Ms. Wyke Huizinga
Dr. Arfan Ikram
Dr. Stefan Klein
Dr. Wiro J. Niessen
Dr. Meike W. Vernooij
  WP3 Data Access & Disease Biomarkers from Large-scale Population Studies
WP6 Multiscale Phenomenological Modelling: Clinical & Environment Factors
WP7 Biomedical Research Platform for Disease Modelling and Model Personalization
WP9 Technology Assessment, Market Analysis and Exploitation
Main competencies:
Erasmus MC University Medical Centre is an innovative academic medical centre for high-quality medical research, education and care. The Erasmus MC conducts one of the largest population-based studies worldwide, the “Rotterdam Study”, a prospective population-based cohort study aimed at investigating determinants of chronic and disabling diseases in the middle-aged and elderly general population. The Rotterdam Study has been ongoing since 1990 and includes nearly 15,000 people aged 45 years and over who live in a district of Rotterdam, the Netherlands. These participants are evaluated for a wide range of genetic, environmental and lifestyle factors – by means of interview, physical and laboratory examinations- and are furthermore followed for occurrence of major
morbidity over time. In 1995 the Departments of Epidemiology & Biostatistics, in close collaboration with the Departments of Radiology and Medical Informatics, initiated the Rotterdam Study, a prospective population-based neuroimaging study among 1077 persons aimed at identifying the structural brain changes that underlie neurodegenerative and cerebrovascular diseases in old age, and investigating their causes.

Contributions to the project
Since 2005, facilitated by the installation of a dedicated 1.5T MR scanner at the Rotterdam Study Research Centre, the Rotterdam Study has expanded and now encompasses all participants of the Rotterdam Study who undergo structural brain imaging at regular time intervals (once every 2 to 3 years). As of May 2012, nearly 7000 persons have undergone brain MRI. Within the scope of the Rotterdam Study, the Biomedical Imaging Group Rotterdam, develops and validates advanced, innovative techniques for the automated processing, integrated analysis, and visualisation of large, multi-modality medical datasets. The departments of Radiology, Medical Informatics and Epidemiology will all be involved in the project, with contributions in Work Packages 3 and 6.